Anti Tissue Transglutaminase IgG

What is transglutaminase IgG?


Tissue Transglutaminase (tTG) Antibody (IgG) – Tissue Transglutaminase Antibody, IgG, is useful in diagnosing gluten-sensitive enteropathies, such as Celiac Sprue Disease, and an associated skin condition, dermatitis herpetiformis in patients who are IgA-deficient.


What does high gluten IgG mean?


A positive AGA-IgG blood test indicates that the body may be mounting an immune system response to gluten ingestion, but it’s considered less specific than other celiac blood tests.


What is the difference between tTG IgA and tTG IgG?


Because IgA antibodies typically predominate in celiac disease, testing for tissue transglutaminase (tTG) IgA antibodies is preferred over tTG IgG antibodies, except in the presence of IgA deficiency. This test should not be solely relied upon to establish a diagnosis of celiac disease.


What causes raised tTG?


Transglutaminase isoform reactivity

Antibodies to tissue transglutaminase (abbreviated as anti-tTG or anti-TG2) are found in patients with several conditions, including celiac disease, juvenile diabetes, inflammatory bowel disease, and various forms of arthritis.


How is this test done?


The test is done with a blood sample. A needle is used to draw blood from a vein in your arm or hand. 


What does positive IgG mean?


The presence of IgG suggests that the infection happened weeks to months in the past. It also suggests that you may no longer be infectious. IgG indicates that you may have some immunity to the virus, though you may not.


What is a good level of IgG?


Reference range/units

Normal Ranges Adult: IgG 6.0 – 16.0g/L. IgA 0.8 – 3.0g/L. IgM 0.4 – 2.5g/L.